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Plant Cell. 2015 Nov;27(11):3175-89. doi: 10.1105/tpc.15.00585. Epub 2015 Nov 3.

Plants Release Precursors of Histone Deacetylase Inhibitors to Suppress Growth of Competitors.

Author information

1
Department of Internal Medicine I, Medical University Clinic, University of Tübingen, 72076 Tübingen, Germany.
2
Agroecology Unit, University of Hohenheim, Institute of Plant Production and Agroecology in the Tropics and Subtropics, 70593 Stuttgart, Germany.
3
Applied Bioinformatics, University of Tübingen, 72076 Tübingen, Germany.
4
Evotec AG, 22419 Hamburg, Germany.
5
Ecology and Evolutionary Biology Section, Institut de Biologie de l'Ecole Normale Supérieure, Ecole Normale Supérieure, Inserm U1024, CNRS UMR 8197, 75005 Paris, France.
6
Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany.
7
Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany claude.becker@tuebingen.mpg.de.

Abstract

To secure their access to water, light, and nutrients, many plant species have developed allelopathic strategies to suppress competitors. To this end, they release into the rhizosphere phytotoxic substances that inhibit the germination and growth of neighbors. Despite the importance of allelopathy in shaping natural plant communities and for agricultural production, the underlying molecular mechanisms are largely unknown. Here, we report that allelochemicals derived from the common class of cyclic hydroxamic acid root exudates directly affect the chromatin-modifying machinery in Arabidopsis thaliana. These allelochemicals inhibit histone deacetylases both in vitro and in vivo and exert their activity through locus-specific alterations of histone acetylation and associated gene expression. Our multilevel analysis collectively shows how plant-plant interactions interfere with a fundamental cellular process, histone acetylation, by targeting an evolutionarily highly conserved class of enzymes.

PMID:
26530086
PMCID:
PMC4682303
DOI:
10.1105/tpc.15.00585
[Indexed for MEDLINE]
Free PMC Article

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