Format

Send to

Choose Destination
PLoS One. 2015 Nov 3;10(11):e0141720. doi: 10.1371/journal.pone.0141720. eCollection 2015.

Insulin Resistance Is Associated with Prevalence of Physician-Diagnosed Urinary Incontinence in Postmenopausal Non-Diabetic Adult Women: Data from the Fourth Korea National Health and Nutrition Examination Survey.

Author information

1
Department of Urology, The Catholic Kwandong University of Korea, International St Mary's hospital, Incheon, Korea.
2
Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
3
Department of Urology, College of Medicine, The Catholic University of Korea, St Paul's hospital, Seoul, Korea.
4
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Yeoido St Mary's hospital, Seoul, Korea.
5
Department of Urology, College of Medicine, The Catholic University of Korea, Yeoido St Mary's hospital, Seoul, Korea.

Abstract

OBJECTIVE:

To investigate the association between insulin resistance (IR) and urinary incontinence in Korean adult women by analyzing the data from the Korea National Health and Nutrition Examination Survey IV (KNHANES) 2007-2009.

METHODS:

A nationally representative sample of 5318 non-diabetic Korean women ≥19-years-of-age (3043 premenopausal and 2275 postmenopausal women) was included from KNHANES 2008-2010. IR was measured using the homeostasis model assessment of IR (HOMA-IR). Participants in the highest and lowest quartile of HOMA-IR were defined as insulin-resistant and insulin-sensitive respectively. Women who have current physician-diagnosed urinary incontinence were classified as having urinary incontinence.

RESULTS:

Incontinence was found in 9.18% of the total population, 8.51% of the premenopausal population, and 10.86% of the postmenopausal population. The prevalence of incontinence increased with age, reaching a peak at 60-69-years-of-age. The prevalence of urinary incontinence increased significantly with higher HOMA-IR quartiles in pre- and post-menopausal women (p for linear association = 0.0458 and 0.0009 respectively). Among post-menopausal women, those in the highest quartile of HOMA-IR were significantly more likely to have urinary incontinence compared to those in the lowest quartile [adjusted odds ratio, 1.72; 95% confidence interval, 1.07-2.77]. However premenopausal population exhibited no association between incontinence and HOMA-IR quartiles.

CONCLUSION:

Our results suggest that the prevalence of incontinence increased across HOMA-IR in non-diabetic adult women, and especially, IR might be a risk factor for incontinence in postmenopausal non-diabetic women.

PMID:
26529410
PMCID:
PMC4631470
DOI:
10.1371/journal.pone.0141720
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center