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Biosens Bioelectron. 2016 Mar 15;77:942-9. doi: 10.1016/j.bios.2015.10.070. Epub 2015 Oct 27.

A new strategy for achieving vertically-erected and hierarchical TiO2 nanosheets array/carbon cloth as a binder-free electrode for protein impregnation, direct electrochemistry and mediator-free glucose sensing.

Author information

1
School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459, Singapore.
2
School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459, Singapore. Electronic address: tytan@ntu.edu.sg.

Abstract

We present a new approach to directly grow uniform and highly-ordered TiO2 nanosheets array (NSA) on a low-cost flexible carbon cloth substrate while simultaneously fulfill precise TiO2 nanostructure tailoring and crystal phase control. The unique vertically-erected TiO2 NSA/carbon cloth with hierarchical structures was directly explored as electrode for enzyme immobilization and biosensing applications without suffering any influences of insulating binders usually used to fix nanomaterials on conductive substrates during sensor fabrications. Efficient direct electron transfer was successfully achieved for glucose oxidase (GOx) immobilized on the TiO2 NSA/carbon cloth, which produces a stable, mediator-free glucose sensor with good selectivity, high-sensitivity (52 μA mM(-1)cm(-2)), low response time (<5s) and low detection limit (23.4 μM, S/N=3). The mechanism of the superior direct electrochemical properties and sensing performance was investigated in detail, and discussed from the aspects of material nanostructure and crystalline form of TiO2 NSA, and an intimate contact between TiO2 and carbon cloth resulted from direct crystallization and growth of TiO2 nanosheets on the substrate.

KEYWORDS:

Carbon cloth; Flexible; Glucose sensing; Mediator-free; TiO(2) nanosheets array

PMID:
26528809
DOI:
10.1016/j.bios.2015.10.070
[Indexed for MEDLINE]

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