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PLoS One. 2015 Nov 3;10(11):e0141825. doi: 10.1371/journal.pone.0141825. eCollection 2015.

Extrapolation-Based References Improve Motion and Eddy-Current Correction of High B-Value DWI Data: Application in Parkinson's Disease Dementia.

Author information

1
Lund University Bioimaging Center, Lund University, Lund, Sweden.
2
Department of Medical Radiation Physics, Lund University, Lund, Sweden.
3
Department of Radiology, Lund University, Lund, Sweden; Imaging and Physiology, Skåne University Hospital, Lund, Sweden.
4
Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Lund, Sweden; Memory Clinic, Skåne University Hospital, Malmö, Sweden.

Abstract

PURPOSE:

Conventional motion and eddy-current correction, where each diffusion-weighted volume is registered to a non diffusion-weighted reference, suffers from poor accuracy for high b-value data. An alternative approach is to extrapolate reference volumes from low b-value data. We aim to compare the performance of conventional and extrapolation-based correction of diffusional kurtosis imaging (DKI) data, and to demonstrate the impact of the correction approach on group comparison studies.

METHODS:

DKI was performed in patients with Parkinson's disease dementia (PDD), and healthy age-matched controls, using b-values of up to 2750 s/mm2. The accuracy of conventional and extrapolation-based correction methods was investigated. Parameters from DTI and DKI were compared between patients and controls in the cingulum and the anterior thalamic projection tract.

RESULTS:

Conventional correction resulted in systematic registration errors for high b-value data. The extrapolation-based methods did not exhibit such errors, yielding more accurate tractography and up to 50% lower standard deviation in DKI metrics. Statistically significant differences were found between patients and controls when using the extrapolation-based motion correction that were not detected when using the conventional method.

CONCLUSION:

We recommend that conventional motion and eddy-current correction should be abandoned for high b-value data in favour of more accurate methods using extrapolation-based references.

PMID:
26528541
PMCID:
PMC4631453
DOI:
10.1371/journal.pone.0141825
[Indexed for MEDLINE]
Free PMC Article

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