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Clujul Med. 2015;88(2):101-10. doi: 10.15386/cjmed-421. Epub 2015 Apr 15.

Management of endometrial modifications in perimenopausal women.

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Dominic Stanca Clinic of Obstetrics and Gynecology, Cluj-Napoca, RomaniaIuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.


Perimenopause has a variable length and time of onset and is characterized by its variability in hormonal levels. The histological changes in the perimenopausal endometrium may be represented by nonproliferative or proliferative benign or malignant lesions. A commonly encountered manifestation of endometrium lesions during menopausal transition is the abnormal uterine bleeding (AUB). The clinical management of AUB must follow a standardized classification system for optimal results. The medical and surgical treatment must be adapted according to age, risk factors, symptoms, and cycle irregularities. Use of alternative therapies and proper diet may result in improved long-term outcomes.


clinical management; endometrium histopathology; perimenopause

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