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Bull Exp Biol Med. 2015 Oct;159(6):740-2. doi: 10.1007/s10517-015-3063-x. Epub 2015 Nov 3.

Effect of α7n-Acetylcholine Receptor Activation and Antibodies to TNF-α on Mortality of Mice and Concentration of Proinflammatory Cytokines During Early Stage of Sepsis.

Author information

1
Saratov Branch of Samara Medical Institute REAVIZ, Saratov, Russia. pfzabrodsky@gmail.com.
2
Saratov Branch of Samara Medical Institute REAVIZ, Saratov, Russia.

Abstract

Experiments on random-bred albino mice showed that activation α7n-acetylcholine receptors with anabasine (0.5 LD50) and the use of antibodies to TNF-α (1 mg/kg) 2 h before sepsis modeling significantly reduces mortality of mice from experimental sepsis (intraperitoneal injection of E. coli) due to a decrease in the blood concentration of proinflammatory cytokines TNF-α, IL-1β, and IL-6. After combined administration of anti-TNF-α antibodies and anabasine, an additive effect was observed.

KEYWORDS:

antibodies to TNF-α; cholinergic anti-inflammatory pathway; proinflammatory cytokines; sepsis; α7n-acetylcholine receptors

PMID:
26525714
DOI:
10.1007/s10517-015-3063-x
[Indexed for MEDLINE]

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