Mixed Phenotype Acute Leukemia with Low Hypodiploidy in a Pediatric Patient

J Pediatr Oncol. 2015;3(1):24-28. doi: 10.14205/2309-3021.2015.03.01.4. Epub 2015 Mar 25.

Abstract

We describe the case of a 16 year-old female with mixed phenotype acute leukemia B/myeloid, NOS (formerly biphenotypic leukemia) with masked hypodiploidy and somatic TP53 and CDKN2A/B deletions. She achieved morphologic remission with lymphoid-directed multi-agent chemotherapy, but experienced an early medullary relapse 11 months from initial diagnosis. Her case details the unusual finding of hypodiploidy in a patient with ambiguous lineage leukemia and highlights the complexity of therapy selection for these high-risk patients.

Keywords: Biphenotypic leukemia; hypodiploidy; mixed phenotype acute leukemia.