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Macromol Rapid Commun. 2016 Jan;37(2):149-54. doi: 10.1002/marc.201500523. Epub 2015 Nov 2.

Controlled-Release System of Small Molecules Triggered by the Photothermal Effect of Polypyrrole.

Author information

1
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, China.
2
State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, China.

Abstract

In this paper, a novel synthesis of polyethylene glycol (PEG)-modified polypyrrole (PPy) nanomaterials is demonstrated by combining reversible addition-fragmentation chain transfer polymerization and oxidative polymerization. Dye molecules with a heat-labile linker are used as a model drug and covalently anchored onto the PEGlated PPy nanomaterials via "click chemistry." The strong absorption of such PPy nanomaterials in the near-infrared region endows the system excellent photothermal effect, which can be used not only as efficient photothermal agents for photothermal therapy but also good controllers of a drug-release system by retro D-A reaction.

KEYWORDS:

NIR light; PPy nanoparticles; controlled-release; photothermal effect; retro D-A reaction

PMID:
26524109
DOI:
10.1002/marc.201500523
[Indexed for MEDLINE]

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