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Nat Neurosci. 2015 Dec;18(12):1722-4. doi: 10.1038/nn.4159. Epub 2015 Nov 2.

Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation.

Author information

1
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
2
The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
3
Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
4
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
5
Pre-doctoral Human Genetics Training Program, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
6
Gilbert Family Neurofibromatosis Institute, Center for Cancer and Immunology Research, Children's National Medical Center, Washington, DC, USA.
7
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Abstract

Endogenous neural stem cells (NSCs) in the adult hippocampus are considered to be bi-potent, as they only produce neurons and astrocytes in vivo. In mouse, we found that inactivation of neurofibromin 1 (Nf1), a gene mutated in neurofibromatosis type 1, unlocked a latent oligodendrocyte lineage potential to produce all three lineages from NSCs in vivo. Our results suggest an avenue for promoting stem cell plasticity by targeting barriers of latent lineage potential.

PMID:
26523645
PMCID:
PMC4661096
DOI:
10.1038/nn.4159
[Indexed for MEDLINE]
Free PMC Article

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