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Neuropsychology. 2016 Jul;30(5):612-23. doi: 10.1037/neu0000241. Epub 2015 Nov 2.

Mechanical problem-solving strategies in Alzheimer's disease and semantic dementia.

Author information

1
Laboratoire d'Etude des Mécanismes Cognitifs (EA 3082), Université de Lyon.
2
Laboratoire de Psychologie des Pays de la Loire (EA 4638), Université d'Angers.
3
Service de Neurologie, Centre Hospitalier Universitaire and Laboratoire de Neuropsychologie, Unité INSERM U 1077.
4
CMRR Grenoble Arc Alpin, Pôle de Psychiatrie et Neurologie, Centre Hospitalier Universitaire de Grenoble.
5
Service de Neuropsychologie, Hôpital Neurologique Pierre Wertheimer.
6
Département de Neurologie, Centre Hospitalier Universitaire d'Angers.

Abstract

OBJECTIVE:

The goal of this study was to explore whether the tool-use disorders observed in Alzheimer's disease (AD) and semantic dementia (SD) are of the same nature as those observed in left brain-damaged (LBD) patients. Recent evidence indicates that LBD patients with apraxia of tool use encounter difficulties in solving mechanical problems, characterized by the absence of specific strategies. This pattern may show the presence of impaired mechanical knowledge, critical for both familiar and novel tool use. So, we explored the strategies followed by AD and SD patients in mechanical problem-solving tasks in order to determine whether mechanical knowledge is also impaired in these patients.

METHOD:

We used a mechanical problem-solving task in both choice (i.e., several tools were proposed) and no-choice (i.e., only 1 tool was proposed) conditions. We analyzed quantitative data and strategy profiles.

RESULTS:

AD patients but not SD patients met difficulties in solving mechanical problem-solving tasks. However, the key finding is that AD patients, despite their difficulties, showed strategy profiles that are similar to that of SD patients or controls. Moreover, AD patients exhibited a strategy profile distinct from the one previously observed in LBD patients.

CONCLUSIONS:

Those observations lead us to consider that difficulties met by AD patients to solve mechanical problems or even to use familiar tools may not be caused by mechanical knowledge impairment per se. In broad terms, what we call apraxia of tool use in AD is certainly not the same as apraxia of tool use observed in LBD patients. (PsycINFO Database Record

PMID:
26523522
DOI:
10.1037/neu0000241
[Indexed for MEDLINE]

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