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Epilepsy Behav. 2015 Nov;52(Pt A):264-6. doi: 10.1016/j.yebeh.2015.07.040. Epub 2015 Nov 6.

Propofol-ketamine combination therapy for effective control of super-refractory status epilepticus.

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Ochsner Medical Center, New Orleans, LA, USA.
Ochsner Medical Center, New Orleans, LA, USA. Electronic address:
Louisiana State University HSC, New Orleans, LA, USA.


Retrospective analysis was conducted of patients with SRSE who were treated simultaneously with propofol and ketamine. Sixty-seven patients were identified from 2012 to 2015, and outcomes documented were resolution and mortality. The duration of combined ketamine and propofol use ranged from 1 to 28 days (mean - 3.6 days). Infusion rates ranged up to 145 and 175 mcg/kg/min. Vasopressors were used in 53 patients (79%), and were given within the first 5 days of the ICU admission in 48 (91%) patients. The overall SRSE resolution rate was 91%, and the overall mortality including patients with anoxic brain injury was 39%. Of the 13 patients with SRSE as a result of anoxic brain injury, SRSE was controlled in 5 (56%). The primary determinant of mortality was family withdrawing care related to the presence of severe medical/neurological diseases.


Anesthetic agents; Ketamine; Mortality; Propofol; Seizure control; Super-refractory status epilepticus; Treatment

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