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ACS Comb Sci. 2015 Nov 9;17(11):658-62. doi: 10.1021/acscombsci.5b00131. Epub 2015 Nov 1.

SAMDI Mass Spectrometry-Enabled High-Throughput Optimization of a Traceless Petasis Reaction.

Author information

1
Department of Chemistry, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.

Abstract

Development of the self-assembled monolayer/MALDI mass spectrometry (SAMDI) platform to enable a high-throughput optimization of a traceless Petasis reaction is described. More than 1800 unique reactions were conducted simultaneously on an array of self-assembled monolayers of alkanethiolates on gold to arrive at optimized conditions, which were then successfully transferred to the solution phase. The utility of this reaction was validated by the efficient synthesis of a variety of di- and trisubstituted allenes.

KEYWORDS:

allenes; high-throughput experimentation; mass spectrometry; reaction optimization; self-assembled monolayers

PMID:
26521847
DOI:
10.1021/acscombsci.5b00131
[Indexed for MEDLINE]

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