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Osteoarthritis Cartilage. 2015 Nov;23(11):1890-6. doi: 10.1016/j.joca.2015.02.009.

Inflammatory biomarkers in osteoarthritis.

Author information

1
Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.
2
Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA; Department of Medicine, Duke University School of Medicine, Durham, NC, USA. Electronic address: vbk@duke.edu.

Abstract

Osteoarthritis (OA) is highly prevalent and a leading cause of disability worldwide. Despite the global burden of OA, diagnostic tests and treatments for the molecular or early subclinical stages are still not available for clinical use. In recent years, there has been a large shift in the understanding of OA as a "wear and tear" disease to an inflammatory disease. This has been demonstrated through various studies using MRI, ultrasound, histochemistry, and biomarkers. It would of great value to be able to readily identify subclinical and/or sub-acute inflammation, particularly in such a way as to be appropriate for a clinical setting. Here we review several types of biomarkers associated with OA in human studies that point to a role of inflammation in OA.

KEYWORDS:

Biomarker; Inflammation; Osteoarthritis

PMID:
26521734
PMCID:
PMC4630669
DOI:
10.1016/j.joca.2015.02.009
[Indexed for MEDLINE]
Free PMC Article

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