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J Biomed Mater Res A. 2016 Mar;104(3):697-706. doi: 10.1002/jbm.a.35609. Epub 2015 Nov 17.

Proliferative activity of elastin-like-peptides depends on charge and phase transition.

Author information

1
Department of Chemical and Biomedical Engineering, University of South Florida, Tampa, Florida, 33620.

Abstract

Elastin-like-peptides (ELPs) are stimulus-responsive protein-based polymers and are attractive biomaterials due to their biocompatibility and unique properties. This study shows that in addition to their physical properties, ELPs have biological activities that are conducive to tissue regeneration. Specifically, we found that ELPs induce fibroblast proliferation via cell surface heparan sulfate proteoglycans (HSPG). Furthermore, our data suggests that ELP based materials with differential proliferative potential can be designed by controlling the interaction of ELPs with HSPGs by incorporating either hydrophobic or positively charged residues within the ELP sequence. Fibroblast proliferation is important for granulation tissue formation which is important in chronic wounds as well as in healing of other tissues. The customizable biological activity of ELPs coupled with their unique physical properties will enable us to design novel, sustainable and cost effective therapies for different tissue regeneration applications.

KEYWORDS:

elastin-like peptides; fibroblast proliferation; tissue regeneration

PMID:
26519668
DOI:
10.1002/jbm.a.35609
[Indexed for MEDLINE]

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