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Nucleic Acids Res. 2016 Jan 4;44(D1):D855-61. doi: 10.1093/nar/gkv1138. Epub 2015 Oct 30.

Deciphering the mechanisms of developmental disorders: phenotype analysis of embryos from mutant mouse lines.

Author information

1
The Francis Crick Institute Mill Hill Laboratory, The Ridgeway, Mill Hill, London NW7 1AA, UK Robert.Wilson@crick.ac.uk.
2
The Francis Crick Institute Mill Hill Laboratory, The Ridgeway, Mill Hill, London NW7 1AA, UK.

Abstract

The Deciphering the Mechanisms of Developmental Disorders (DMDD) consortium is a research programme set up to identify genes in the mouse, which if mutated (or knocked-out) result in embryonic lethality when homozygous, and initiate the study of why disruption of their function has such profound effects on embryo development and survival. The project uses a combination of comprehensive high resolution 3D imaging and tissue histology to identify abnormalities in embryo and placental structures of embryonic lethal lines. The image data we have collected and the phenotypes scored are freely available through the project website (http://dmdd.org.uk). In this article we describe the web interface to the images that allows the embryo data to be viewed at full resolution in different planes, discuss how to search the database for a phenotype, and our approach to organising the data for an embryo and a mutant line so it is easy to comprehend and intuitive to navigate.

PMID:
26519470
PMCID:
PMC4702824
DOI:
10.1093/nar/gkv1138
[Indexed for MEDLINE]
Free PMC Article

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