Successful Pancreas Transplantation From a Deceased Donor Intoxicated With Oral Antidiabetic Agent: A Case Report

Transplant Proc. 2015 Oct;47(8):2404-6. doi: 10.1016/j.transproceed.2015.08.028.

Abstract

Simultaneous kidney pancreas transplantation (SKP) is a common procedure for the patient with long-term type 1 diabetes mellitus (DM) with terminal renal failure. It is unusual to consider the pancreas from a deceased donor who died after an acute intoxication with oral antidiabetic agent (OAA), which would suggest an abnormal functionality of the organ and preclude the potential use of the graft. We present a case of a successful pancreatic transplantation from a donor who died of acute cerebral edema secondary to severe hypoglycemia induced by OAA acute intoxication.

Publication types

  • Case Reports

MeSH terms

  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / surgery*
  • Diabetic Nephropathies / surgery*
  • Drug Overdose*
  • Female
  • Glyburide / poisoning*
  • Humans
  • Hypoglycemic Agents / poisoning*
  • Kidney Failure, Chronic / etiology
  • Kidney Failure, Chronic / surgery*
  • Kidney Transplantation / methods*
  • Male
  • Middle Aged
  • Pancreas Transplantation / methods*
  • Suicide
  • Tissue Donors*
  • Treatment Outcome

Substances

  • Hypoglycemic Agents
  • Glyburide