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Dent Mater. 2015 Dec;31(12):1493-501. doi: 10.1016/j.dental.2015.09.019. Epub 2015 Oct 28.

Functional monomer impurity affects adhesive performance.

Author information

1
Center for Innovative Clinical Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. Electronic address: k-yoshi@md.okayama-u.ac.jp.
2
Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. Electronic address: nagaoka@okayama-u.ac.jp.
3
Division of Chemical and Biological Technology, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan. Electronic address: okihara@cc.okayama-u.ac.jp.
4
Division of Chemical and Biological Technology, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan. Electronic address: mkurohos@cc.okayama-u.ac.jp.
5
Biomaterials Laboratory Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan. Electronic address: satoshi@okayama-u.ac.jp.
6
Department of Occlusion and Removable Prosthodontics, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. Electronic address: ykmar@md.okayama-u.ac.jp.
7
Department of Occlusion and Removable Prosthodontics, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. Electronic address: goro@md.okayama-u.ac.jp.
8
BIOMAT, Department of Oral Health Research, KU Leuven (University of Leuven) & Dentistry, University Hospitals Leuven, Kapucijnenvoer 7 blok a bus 7001, B-3000 Leuven, Belgium. Electronic address: jan.demunck@med.kuleuven.be.
9
Department of Biomaterials and Bioengineering, Graduate School of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo, Hokkaido 060-8586, Japan. Electronic address: yasuhiro@den.hokudai.ac.jp.
10
BIOMAT, Department of Oral Health Research, KU Leuven (University of Leuven) & Dentistry, University Hospitals Leuven, Kapucijnenvoer 7 blok a bus 7001, B-3000 Leuven, Belgium. Electronic address: bart.vanmeerbeek@med.kuleuven.be.

Abstract

OBJECTIVE:

The functional monomer 10-MDP has been considered as one of the best performing functional monomers for dental adhesives. Different adhesives containing 10-MDP are commercially available, among which many so-called 'universal' adhesives. We hypothesize that the quality of the functional monomer 10-MDP in terms of purity may affect bonding performance.

METHODS:

We therefore characterized three different 10-MDP versions (10-MDP_KN provided by Kuraray Noritake; 10-MDP_PCM provided by PCM; 10-MDP_DMI provided by DMI) using NMR, and analyzed their ability to form 10-MDP_Ca salts on dentin using XRD. The 'immediate' and 'aged' micro-tensile bond strength (μTBS) to dentin of three experimental 10-MDP primers was measured. The resultant interfacial adhesive-dentin ultra-structure was characterized using TEM.

RESULTS:

NMR disclosed impurities and the presence of 10-MDP dimer in 10-MDP_PCM and 10-MDP_DMI. 10-MDP_PCM and 10-MDP_DMI appeared also sensitive to hydrolysis. 10-MDP_KN, on the contrary, contained less impurities and dimer, and did not undergo hydrolysis. XRD revealed more intense 10-MDP_Ca salt deposition on dentin induced by 10-MDP_KN. The adhesive based on the experimental 10-MDP_KN primer resulted in a significantly higher 'immediate' bond strength that remained stable upon aging; the μTBS of the experimental 10-MDP_PCM and 10-MDP_DMI adhesives significantly dropped upon aging. TEM revealed thicker hybridization and more intense nano-layering for 10-MDP_KN.

SIGNIFICANCE:

It was concluded that primer impurities and the presence of 10-MDP dimer affected not only hybridization, but also reduced the formation of 10-MDP_Ca salts and nano-layering. 10-MDP in a high purity grade is essential to achieve durable bonding.

KEYWORDS:

Adhesion; Dentin; Functional monomer; Impurity; NMR; TEM

PMID:
26518339
DOI:
10.1016/j.dental.2015.09.019
[Indexed for MEDLINE]

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