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J Neural Transm (Vienna). 2017 Feb;124(Suppl 1):163-178. doi: 10.1007/s00702-015-1476-3. Epub 2015 Oct 30.

Sleep-dependent memory consolidation and its implications for psychiatry.

Author information

1
German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany. monique.goerke@med.uni-rostock.de.
2
Department of Psychiatry and Psychotherapy, University of Rostock, Gehlsheimer Str. 20, 18147, Rostock, Germany. monique.goerke@med.uni-rostock.de.
3
German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
4
Department of Psychiatry and Psychotherapy, University of Rostock, Gehlsheimer Str. 20, 18147, Rostock, Germany.

Abstract

Both sleep disturbance and memory impairment are very common in psychiatric disorders. Since sleep has been shown to play a role in the process of transferring newly acquired information into long-term memory, i.e., consolidation, it is important to highlight this link in the context of psychiatric disorders. Along these lines, after providing a brief overview of healthy human sleep, current neurobiological models on sleep-dependent memory consolidation and resultant opportunities to manipulate the memory consolidation process, recent findings on sleep disturbances and sleep-dependent memory consolidation in patients with insomnia, major depression, schizophrenia, and post-traumatic stress disorder are systematically reviewed. Furthermore, possible underlying neuropathologies and their implications on therapeutic strategies are discussed. This review aims at sensitizing the reader for recognizing sleep disturbances as a potential contributor to cognitive deficits in several disorders, a fact which is often overlooked up to date.

KEYWORDS:

Insomnia; Major depression; Memory consolidation; Post-traumatic stress disorder; Schizophrenia; Sleep

PMID:
26518213
DOI:
10.1007/s00702-015-1476-3
[Indexed for MEDLINE]

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