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J Am Acad Dermatol. 2016 Feb;74(2):295-302. doi: 10.1016/j.jaad.2015.08.063. Epub 2015 Oct 27.

Comorbid autoimmune diseases in patients with vitiligo: A cross-sectional study.

Author information

1
College of Human Medicine, Michigan State University, East Lansing, Michigan.
2
Wayne State University School of Medicine, Detroit, Michigan.
3
Vitiligo Research and Treatment Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.
4
Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan.
5
Vitiligo Research and Treatment Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan. Electronic address: ihamzav1@hfhs.org.

Abstract

BACKGROUND:

Few large-scale studies have quantified the burden of comorbid autoimmune diseases in patients with vitiligo.

OBJECTIVE:

We sought to determine the prevalence of comorbid autoimmune diseases in patients with vitiligo.

METHODS:

We conducted a manual chart review on a cohort of 1873 patients with vitiligo seen between January 2002 and October 2012 at the Henry Ford Health System in Detroit, MI. Patients were excluded if they had fewer than 2 dermatology notes (N = 595) or if they were never given a diagnosis of vitiligo by a dermatologist (N = 180).

RESULTS:

Of 1098 patients with vitiligo, nearly 20% had at least 1 comorbid autoimmune disease. Compared with the general US population, we found a higher prevalence of thyroid disease (12.9%, P < .001), alopecia areata (3.8%, P < .001), inflammatory bowel disease (0.9%, P = .046), pernicious anemia (0.5%, P = .007), systemic lupus erythematosus (0.3%, P = .048), Guillain-Barre syndrome (0.3%, P < .001), discoid lupus (0.2%, P = .003), linear morphea (0.2%, P < .001), myasthenia gravis (0.2%, P = .002), and Sjögren syndrome (0.2%, P = .011).

LIMITATIONS:

The study lacked a control group. This was a single-institution study with possible selection bias, and thus the findings may not be representative of the overall population of patients with vitiligo.

CONCLUSIONS:

We observed a high prevalence of comorbid autoimmune diseases in patients with vitiligo and report several new associations.

KEYWORDS:

alopecia areata; associations; autoimmune disease; comorbidities; prevalence; thyroid disease; vitiligo

PMID:
26518171
DOI:
10.1016/j.jaad.2015.08.063
[Indexed for MEDLINE]

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