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Biochem Soc Trans. 2015 Oct;43(5):1122-6. doi: 10.1042/BST20150124.

Oncosuppressive functions of tribbles pseudokinase 3.

Author information

1
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain Instituto de Investigaciones Sanitarias San Carlos (IdISSC), 28040 Madrid, Spain.
2
Departament de Bioquímica i Biologia Molecular, Institut de Neurociències, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, Barcelona 08193, Spain.
3
CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Spain Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), 48940 Bilbao, Spain.
4
Department of Cardiovascular Science, University of Sheffield, Sheffield S10 2RX, U.K.
5
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain Instituto de Investigaciones Sanitarias San Carlos (IdISSC), 28040 Madrid, Spain gvelasco@ucm.es.

Abstract

Tribbles pseudokinase 3 (TRIB3) belongs to the tribbles family of pseudokinases. In this article, we summarize several observation obtained by our laboratories supporting that TRIB3 plays a crucial role in the anti-cancer activity of cannabinoids (a novel family of potential anti-cancer agents derived from marijuana) and that TRIB3 genetic inactivation enhances cancer generation and progression.

KEYWORDS:

animal models of cancer; autophagy; cannabinoids; endoplasmic reticulum (ER) stress; tribbles pseudokinases

PMID:
26517935
DOI:
10.1042/BST20150124
[Indexed for MEDLINE]

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