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Oncotarget. 2015 Dec 8;6(39):42312-21. doi: 10.18632/oncotarget.5994.

Germline HOXB13 p.Gly84Glu mutation and cancer susceptibility: a pooled analysis of 25 epidemiological studies with 145,257 participates.

Author information

1
Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
2
Department of Radiotherapy, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
3
Pharmaceutical Department, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.
4
Library of Tianjin Medical University, Tianjin Medical University, Tianjin, 300070, China.
5
Tianjin Institute of Infectious Diseases, The Second Hospital of Tianjin Medical University, Tianjin, 300211, China.

Abstract

Numerous studies have investigated association between the germline HOXB13 p.Gly84Glu mutation and cancer risk. However, the results were inconsistent. Herein, we performed this meta-analysis to get a precise conclusion of the associations. A comprehensive literature search was conducted through Medline (mainly Pubmed), Embase, Cochrane Library databases. Crude odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated by STATA 12.1 software to evaluate the association of HOXB13 p.Gly84Glu mutation and cancer susceptibility. Then, 25 studies including 51,390 cases and 93,867 controls were included, and there was significant association between HOXB13 p.Gly84Glu mutation and overall cancer risk (OR = 2.872, 95% CI = 2.121-3.888, P < 0.001), particularly in prostate cancer (OR = 3.248, 95% CI = 2.313-4.560, P < 0.001), while no association was found in breast (OR = 1.424, 95% CI = 0.776-2.613, P = 0.253) and colorectal cancers (OR = 2.070, 95% CI = 0.485-8.841, P = 0.326). When we stratified analysis by ethnicity, significant association was found in Caucasians (OR = 2.673, 95%CI = 1.920-3.720, P < 0.001). Further well-designed with large samples and other various cancers should be performed to validate our results.

KEYWORDS:

HOXB13 gene; cancer; genetic mutation; risk; rs138213197

PMID:
26517352
PMCID:
PMC4747227
DOI:
10.18632/oncotarget.5994
[Indexed for MEDLINE]
Free PMC Article

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