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EMBO J. 2015 Dec 2;34(23):2865-84. doi: 10.15252/embj.201592655. Epub 2015 Oct 29.

Long non-coding RNAs in corticogenesis: deciphering the non-coding code of the brain.

Author information

1
DFG-Research Center and Cluster of Excellence for Regenerative Therapies, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
2
DFG-Research Center and Cluster of Excellence for Regenerative Therapies, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany federico.calegari@crt-dresden.de.

Abstract

Evidence on the role of long non-coding (lnc) RNAs has been accumulating over decades, but it has been only recently that advances in sequencing technologies have allowed the field to fully appreciate their abundance and diversity. Despite this, only a handful of lncRNAs have been phenotypically or mechanistically studied. Moreover, novel lncRNAs and new classes of RNAs are being discovered at growing pace, suggesting that this class of molecules may have functions as diverse as protein-coding genes. Interestingly, the brain is the organ where lncRNAs have the most peculiar features including the highest number of lncRNAs that are expressed, proportion of tissue-specific lncRNAs and highest signals of evolutionary conservation. In this work, we critically review the current knowledge about the steps that have led to the identification of the non-coding transcriptome including the general features of lncRNAs in different contexts in terms of both their genomic organisation, evolutionary origin, patterns of expression, and function in the developing and adult mammalian brain.

KEYWORDS:

brain development; long non‐coding RNAs; neural stem cells

PMID:
26516210
PMCID:
PMC4687686
DOI:
10.15252/embj.201592655
[Indexed for MEDLINE]
Free PMC Article

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