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Autoimmunity. 2016;49(1):31-40. doi: 10.3109/08916934.2015.1101071. Epub 2015 Oct 30.

Interleukin-17A rs2275913, Interleukin-17F rs763780 and rs2397084 gene polymorphisms as possible risk factors in Juvenile lupus and lupus related nephritis.

Author information

1
a Pediatric Nephrology Unit, Mansoura University Children's Hospital , Mansoura , Egypt .
2
b Clinical Immunology Unit, Clinical Pathology Department & Mansoura Research Center for Cord Stem Cells (MARC_CSC), Faculty of Medicine, Mansoura University , Mansoura , Egypt .
3
c Rheumatology and Rehabilitation Department, Mansoura University Hospital , Mansoura , Egypt .
4
d Dermatology and Andrology Department, Mansoura Faculty of Medicine , Mansoura , Egypt .
5
e Clinical Hematology Unit, Clinical Pathology Department, Faculty of Medicine, Mansoura University , Mansoura , Egypt .
6
f Pediatric Cardiology Unit and.
7
g Genetics Unit, Mansoura University Children's Hospital , Mansoura , Egypt , and.
8
h Laboratory Medicine Department , Mansoura Fever Hospital, Ministry of Health , Mansoura , Egypt.

Abstract

There are no reports about the association of interleukin (IL)-17A and IL-17F gene polymorphism and susceptibility to pediatric systemic lupus erythematosus (pSLE).

OBJECTIVE:

To examine the possible role of IL-17A rs2275913, IL-17F rs763780 and rs2397084 polymorphisms as risk factors for pSLE in a cohort of Egyptian children and to investigate their association with the clinico-pathological features including lupus nephritis (LN).

METHODS:

Typing of IL-17A and IL-17F polymorphisms was done using restriction fragment length polymorphism for 115 children with SLE and 259 age- and sex-matched healthy controls.

RESULTS:

No significant differences were found between pSLE patients and healthy controls for the allele and genotype frequencies of IL-17A rs2275913, IL-17F rs763780 and rs2397084 (p > 0.05). However, the combined genotype GGAGAA and the haplotype GGA had significant association with pSLE (pc = 0.042 and <0.001, respectively). The AA genotype of IL-17F rs763780 is more frequent in female patients (p = 0.002) and the AA genotype of IL-17F rs2397084 is more associated with positivity of ds-DNA (p = 0.007). No more associations were found for the demographic and clinical data of pSLE patients including risk of LN development, risk of non-remission, overall survival, activity and chronicity indices.

CONCLUSION:

The GGAGAA combined genotype and the GGA haplotype of IL-17A rs2275913, IL-17F rs763780 and rs2397084 can be considered risk factors for the development of SLE in Egyptian children. IL-17A rs2275913, IL-17F rs763780 and rs2397084 are not related to the LN development, SLE disease activity or overall survival.

KEYWORDS:

Egyptian; IL-17; Juvenile; SLE; SNPs; nephritis

PMID:
26515887
DOI:
10.3109/08916934.2015.1101071
[Indexed for MEDLINE]

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