Role of Interleukin-4, Interleukin-10, and Tumor Necrosis Factor-α Polymorphic Genes in the Pathogenesis of Occupational Allergic Dermatoses

L P Kuz'mina; N I Izmerova; M M Kolyaskina

doi:10.1007/s10517-015-3074-7

Role of Interleukin-4, Interleukin-10, and Tumor Necrosis Factor-α Polymorphic Genes in the Pathogenesis of Occupational Allergic Dermatoses

Bull Exp Biol Med. 2015 Oct;159(6):779-81. doi: 10.1007/s10517-015-3074-7. Epub 2015 Oct 29.

Authors

L P Kuz'mina¹, N I Izmerova², M M Kolyaskina²

Affiliations

¹ Research Institute of Labor Medicine, Moscow, Russia. lpkuzmina@mail.ru.
² Research Institute of Labor Medicine, Moscow, Russia.

PMID: 26515179
DOI: 10.1007/s10517-015-3074-7

Abstract

Study of polymorphic genes of pro- and anti-inflammatory cytokines (IL-4, IL-10, TNF-α) in patients with occupational allergic dermatoses showed significantly higher frequency of polymorphic variants of cytokine genes IL4 C589T, IL10 C819T, IL10 G1082A, IL10 C592A, and TNF G308A in comparison with the population control. The presence of homozygous variant IL10 G1082A--AA in 80% cases characterizes early disease development, i.e. within 3 years after the first exposure to the occupational factor.

Keywords: cytokines; individual liability; occupational allergic dermatoses.

MeSH terms

Amino Acid Substitution
Asthma / epidemiology
Asthma / genetics
Case-Control Studies
Dermatitis, Atopic / epidemiology
Dermatitis, Atopic / genetics*
Eczema / epidemiology
Eczema / genetics
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Interleukin-10 / genetics*
Interleukin-4 / genetics*
Occupational Diseases / epidemiology
Occupational Diseases / genetics*
Polymorphism, Single Nucleotide
Tumor Necrosis Factor-alpha / genetics*

Substances

IL10 protein, human
IL4 protein, human
Tumor Necrosis Factor-alpha
Interleukin-10
Interleukin-4