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BMC Biol. 2015 Oct 29;13:89. doi: 10.1186/s12915-015-0201-x.

Structure and function of mitochondrial membrane protein complexes.

Author information

1
Department of Structural Biology, Max Planck Institute of Biophysics, Max von Laue Str. 3, D-60438, Frankfurt am Main, Germany. werner.kuehlbrandt@biophys.mpg.de.

Abstract

Biological energy conversion in mitochondria is carried out by the membrane protein complexes of the respiratory chain and the mitochondrial ATP synthase in the inner membrane cristae. Recent advances in electron cryomicroscopy have made possible new insights into the structural and functional arrangement of these complexes in the membrane, and how they change with age. This review places these advances in the context of what is already known, and discusses the fundamental questions that remain open but can now be approached.

PMID:
26515107
PMCID:
PMC4625866
DOI:
10.1186/s12915-015-0201-x
[Indexed for MEDLINE]
Free PMC Article

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