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Nat Cell Biol. 2015 Nov;17(11):1373-5. doi: 10.1038/ncb3261.

Endosomal integrin signals for survival.

Author information

1
Cancer Research UK, Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.

Abstract

The mechanisms underlying integrin-dependent signalling are a topic of continued study. Endocytosed integrins are now shown to drive assembly of signalling complexes on the cytoplasmic face of endocytic membranes to promote cancer cell survival and increase metastatic capacity following cell detachment.

PMID:
26515017
DOI:
10.1038/ncb3261
[Indexed for MEDLINE]
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