Format

Send to

Choose Destination
Eur Child Adolesc Psychiatry. 2016 Apr;25(4):341-50. doi: 10.1007/s00787-015-0786-1. Epub 2015 Oct 29.

Serum concentration of 25-hydroxyvitamin D in autism spectrum disorder: a systematic review and meta-analysis.

Author information

1
Department of Pediatric Neurology and Neurorehabilitation, The First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, Jilin, 130021, China.
2
Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
3
Department of Psychiatry and Donders Centre for Neuroscience, Radboud University Nijmegen Medical Centre Karakter, Centre for Child and Adolescent Psychiatry Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands.
4
Department of Pediatric Neurology and Neurorehabilitation, The First Hospital of Jilin University, No. 71, Xinmin Street, Changchun, Jilin, 130021, China. erkekangfujia@163.com.
5
Institute of Pediatrics of First Hospital of Jilin University Changchun, Changchun, 130021, China. erkekangfujia@163.com.
6
Neurological Research Center of First Hospital of Jilin University, Changchun, 130021, China. erkekangfujia@163.com.

Abstract

Vitamin D may play an important role in the etiology of Autism Spectrum Disorders (ASD). Vitamin D is regarded as a neuroactive steroid affecting brain development and function. It plays an essential role in myelination, which is important for connectivity in the brain. Studies have shown that decreased vitamin D levels in patients, decreased maternal vitamin D levels during pregnancy, and decreased exposure to solar UVB might increase the risk for ASD. In addition, autism symptoms and global functioning may improve after vitamin D supplementation. Here, we sought to aggregate information from previous publications on vitamin D levels and ASD, in order to achieve a higher statistical power and thereby to determine the validity of vitamin D deficiency as a risk factor for ASD. For this meta-analysis, 11 studies met the inclusion and exclusion criteria, accounting for a total of 870 ASD patients and 782 healthy controls. Levels of serum 25(OH) D in participants with ASD were significantly lower than controls, suggesting that lower vitamin D level might be a risk factor for ASD.

KEYWORDS:

Autism spectrum disorders; Meta-analysis; Review; Vitamin D

PMID:
26514973
DOI:
10.1007/s00787-015-0786-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center