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AJNR Am J Neuroradiol. 2016 Mar;37(3):423-9. doi: 10.3174/ajnr.A4541. Epub 2015 Oct 29.

Prominence of Medullary Veins on Susceptibility-Weighted Images Provides Prognostic Information in Patients with Subacute Stroke.

Author information

1
From the Departments of Radiology (X.Y., J.S., P.H., X.X., M.Z.).
2
Department of Biomedical Engineering and Instrument Science (L.Y.), Key Laboratory for Biomedical Engineering of Education Ministry of China, Zhejiang University, Hangzhou, China.
3
Wolfson Molecular Imaging Centre (A.J.), University of Manchester, Manchester, United Kingdom.
4
Neurology (Y.M., M.L.), Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
5
Department of Neurology (Q.J.), Henry Ford Health System, Detroit, Michigan.
6
From the Departments of Radiology (X.Y., J.S., P.H., X.X., M.Z.) zhangminming@zju.edu.cn.

Abstract

BACKGROUND AND PURPOSE:

The demonstration of prominent medullary veins in the deep white matter ipsilateral to acute ischemic stroke has been shown to predict poor clinical outcome. We have investigated the prognostic implications of prominent medullary veins in patients with subacute stroke who present outside the therapeutic window for revascularization therapy.

MATERIALS AND METHODS:

Forty-three consecutive patients with ischemic stroke in the middle cerebral artery territory presenting within 3-7 days of ictus were enrolled. The presence of prominent medullary veins in the periventricular white matter of the ipsilateral and contralateral medullary vein hemispheres was recorded. Perfusion-weighted imaging was used to calculate differences in hemispheric CBF from corresponding areas. Clinical outcome was classified as good if the modified Rankin Scale score was <3.

RESULTS:

Prominent medullary veins were observed in 24/43 patients with 14 ipsilateral medullary veins and 10 contralateral medullary veins. The ipsilateral medullary vein was independently associated with poor outcome (odds ratio, 11.19; P = .046). The contralateral medullary vein was not independently predictive of outcome but was significantly more common in patients with good outcome (90.0% contralateral medullary veins). A mean 64.5% decrease and a 52.4% increase of differences in hemispheric CBF were found in ipsilateral medullary veins and contralateral medullary veins, respectively.

CONCLUSIONS:

The ipsilateral medullary vein was a significant predictive biomarker of poor clinical outcome after stroke and was associated with hypoperfusion. The contralateral medullary vein was associated with good clinical outcome, and we hypothesize that prominent contralateral medullary veins indirectly reflect increased CBF in the ipsilateral hemisphere due to spontaneous recanalization or collateral flow.

PMID:
26514606
DOI:
10.3174/ajnr.A4541
[Indexed for MEDLINE]
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