Format

Send to

Choose Destination
Int J Mol Sci. 2015 Oct 23;16(10):25392-432. doi: 10.3390/ijms161025392.

Changes in Regenerative Capacity through Lifespan.

Author information

1
Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK. maximina.yun@ucl.ac.uk.

Abstract

Most organisms experience changes in regenerative abilities through their lifespan. During aging, numerous tissues exhibit a progressive decline in homeostasis and regeneration that results in tissue degeneration, malfunction and pathology. The mechanisms responsible for this decay are both cell intrinsic, such as cellular senescence, as well as cell-extrinsic, such as changes in the regenerative environment. Understanding how these mechanisms impact on regenerative processes is essential to devise therapeutic approaches to improve tissue regeneration and extend healthspan. This review offers an overview of how regenerative abilities change through lifespan in various organisms, the factors that underlie such changes and the avenues for therapeutic intervention. It focuses on established models of mammalian regeneration as well as on models in which regenerative abilities do not decline with age, as these can deliver valuable insights for our understanding of the interplay between regeneration and aging.

KEYWORDS:

aging; axolotl; newt; planaria; regeneration; reprogramming; senescence; stem cells; zebrafish

PMID:
26512653
PMCID:
PMC4632807
DOI:
10.3390/ijms161025392
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center