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Medicine (Baltimore). 2015 Oct;94(43):e1816. doi: 10.1097/MD.0000000000001816.

Current Epidemiology and Outcome of Infective Endocarditis: A Multicenter, Prospective, Cohort Study.

Collaborators (211)

Fernández Sánchez F, Noureddine M, Rosas G, de la Torre Lima J, Aramendi J, Bereciartua E, Boado MV, Campaña Lázaro M, Goikoetxea J, Goiti JJ, Hernández JL, Iruretagoyena JR, Zuazabal JI, Martínez I, Pérez PM, Rodríguez R, Voces R, García López MV, Georgieva RI, Márquez Solero M, Rodríguez Bailón I, Ruiz Morales J, Cuende AM, Idígoras P, Iribarren JA, Izaguirre Yarza A, Reviejo C, Echeverría T, Gaminde E, Goenaga MA, Fuertes A, Carrasco R, Climent V, Llamas P, Merino E, Plazas J, Reus S, Alvarez N, Bravo-Ferrer JM, Regueiro DS, Sanchez E, Castelo L, Cuenca J, Miguez Rey E, Rodríguez Mayo M, Llinares P, Sanchez E, Lomas JM, Martínez FJ, Alonso Mdel M, Castro B, García Marrero D, Durán Mdel C, Miguel Gómez MA, La Calzada J, Nassar I, Plata Ciezar A, Reguera Iglesias JM, Asensi Alvarez V, Costas C, de la Hera J, Fernández Suárez J, García Ruiz JM, Iglesias Fraile L, López Menéndez J, Mencia Bajo P, Morales C, Moreno Torrico A, Palomo C, Péérez F, Rodríguez A, Telenti M, Almela M, Armero Y, Azqueta M, Castañeda X, Cervera C, Falces C, García de la Maria C, Gatell JM, Heras M, Llopis Pérez J, Marco F, Miró JM, Mestres CA, Moreno A, Ninot S, Ramírez J, Sitges M, Paré C, Pericás JM, Bouza E, Bermejo J, AliaEworo, Fernández Cruz A, González del Vecchio M, González Ramallo V, Kestler M, Marín M, Martínez-Sellés M, Cruz Menárguez M, Muñoz P, Rodríguez-Abella H, Rodríguez-Créixems M, Rodríguez Roda J, Salas M, Segado A, Pinilla B, Pinto A, Valerio M, Verde E, Antorrena I, Fraile Vicente JM, García Cerrada C, García Guereta L, Lorenao Hernández A, Quirós AM, Moreno M, Paño JR, Quesada Simón MA, Rico M, Rodríguez Dávila MA, Romero M, Rosillo S, Rico Nieto A, Rico M, Romero M, Arnaiz A, Berrazueta J, Bellisco S, Cobo Belaustegui M, Durán R, Fariñas-Alvarez C, Fernández Mazarrasa C, Gómez Izquierdo R, González Rico C, Gutiérrez Díez J, Martín Durán R, Pajarón M, Parra JA, Teira R, Zarauza J, García Pavía P, González J, Orden B, Ramos A, Rodríguez González E, Centella T, Hermida J, Moya J, Martínez P, Navas E, Oliva E, del Río A, Ruiz S, Martínez C, Nodar A, Pérez R, Vasallo FJ, Hidalgo Tenorio C, de Castro A, de Cueto M, Gallego P, Rodríguez Baño J, de Alarcón A, García E, Haro JL, Lepe JA, López F, Luque R, Alonso LJ, Blanco JR, García L, Oteo JA, de Benito N, Gurguí M, Pacho C, Pericas R, Pons G, Alvarez M, Fernández AL, Martínez A, Prieto A, Regueiro B, Tijeira E, Vega M, Canut Blasco A, Cordo Mollar J, Gainzarain Arana JC, García Uriarte O, Martín López A, Ortiz de Zárate Z, Urturi Matos JA, Nacle MB, Sánchez A, Vallejo L, Arribas Leal JM, García Vázquez E, Hernández Torres A, Ruiz Gómez J, de la Morena Valenzuela G, Bayón N, Díaz MD, Durán D, Rodríguez JC, Moreno A, Alonso A, Aramburu J, Calvo FE, Moreno Rodríguez A, Tarabini-Castellani P.

Author information

1
From the Hospital General Universitario Gregorio Marañon (PM, MK, JB, HR-A, EB), Madrid; Medicine Department (PM, MK, JB, HR-A, EB), School of Medicine, Universidad Complutense de Madrid; H Valdecilla (MCF, MCB), Santander; Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva. Hospital, Universitario Virven del Rocío, Sevilla (ADA), Sevilla; H Clinic-IDIBAPS (JMM, CM), University of Barcelona, Barcelona; Complejo Hospitalario Universitario A Coruña (PL), A Coruña; H Donosti Policlinica Gipuzkoa (MG), San Sebastián; H Ramón y Cajal (EN), Madrid; H San Pedro (JAO), La Rioja; Hospital Universitario de Álava, sede Txagorritxu (PT), Vitoria; and CIBER de Enfermedades Respiratorias-CIBERES (CB06/06/0058) (EB, PM), Madrid, Spain.

Abstract

The aim of the study was to describe the epidemiologic and clinical characteristics and identify the risk factors of short-term and 1-year mortality in a recent cohort of patients with infective endocarditis (IE).From January 2008, multidisciplinary teams have prospectively collected all consecutive cases of IE, diagnosed according to the Duke criteria, in 25 Spanish hospitals.Overall, 1804 patients were diagnosed. The median age was 69 years (interquartile range, 55-77), 68.0% were men, and 37.1% of the cases were nosocomial or health care-related IE. Gram-positive microorganisms accounted for 79.3% of the episodes, followed by Gram-negative (5.2%), fungi (2.4%), anaerobes (0.9%), polymicrobial infections (1.9%), and unknown etiology (9.1%). Heart surgery was performed in 44.2%, and in-hospital mortality was 28.8%. Risk factors for in-hospital mortality were age, previous heart surgery, cerebrovascular disease, atrial fibrillation, Staphylococcus or Candida etiology, intracardiac complications, heart failure, and septic shock. The 1-year independent risk factors for mortality were age (odds ratio [OR], 1.02), neoplasia (OR, 2.46), renal insufficiency (OR, 1.59), and heart failure (OR, 4.42). Surgery was an independent protective factor for 1-year mortality (OR, 0.44).IE remains a severe disease with a high rate of in-hospital (28.9%) and 1-year mortality (11.2%). Surgery was the only intervention that significantly reduced 1-year mortality.

PMID:
26512582
PMCID:
PMC4985396
DOI:
10.1097/MD.0000000000001816
[Indexed for MEDLINE]
Free PMC Article

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