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Open Forum Infect Dis. 2015 Sep 19;2(4):ofv135. doi: 10.1093/ofid/ofv135. eCollection 2015 Dec.

In-Hospital Pneumococcal Polysaccharide Vaccination Is Associated With Detection of Pneumococcal Vaccine Serotypes in Adults Hospitalized for Community-Acquired Pneumonia.

Author information

1
Vanderbilt University School of Medicine , Nashville, Tennessee ; Geriatric Research Education Clinical Center , VA Tennessee Valley , Nashville.
2
Northwestern University-Feinberg School of Medicine.
3
Vanderbilt University School of Medicine , Nashville, Tennessee.
4
Rush University School of Medicine.
5
John H. Stroger, Jr. Hospital of Cook County , Chicago, Illinois.
6
Emory University School of Medicine , Atlanta, Georgia.
7
University of Tennessee Health Science Center/Saint Thomas Health , Nashville.
8
University of Utah School of Medicine , Salt Lake City.
9
Centers for Disease Control and Prevention , Atlanta, Georgia.

Abstract

During an etiology study of adults hospitalized for pneumonia, in which urine specimens were examined for serotype-specific pneumococcal antigen detection, we observed that some patients received 23-valent pneumococcal polysaccharide vaccine before urine collection. Some urine samples became positive for specific vaccine pneumococcal serotypes shortly after vaccination, suggesting false-positive test results.

KEYWORDS:

antigen; pneumococcal conjugate vaccine; pneumonia; serotype; urine

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