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Neuroimage Clin. 2015 Sep 3;9:385-91. doi: 10.1016/j.nicl.2015.08.013. eCollection 2015.

Factoring the brain signatures of anesthesia concentration and level of arousal across individuals.

Author information

1
Universidad Torcuato di Tella, Almirante Juan Saenz Valiente 1010, Buenos Aires C1428BIJ, Argentina ; Cognitive Neuroimaging Unit, CEA DSV/I2BM, INSERM, Université Paris-Sud, Université Paris-Saclay, NeuroSpin center, 91191 Gif/Yvette, France.
2
Cognition and Brain Sciences Unit, Medical Research Council, Cambridge CB2 7EF, UK ; Department of Psychology, University of Cambridge, Cambridge, UK.
3
Universidad Torcuato di Tella, Almirante Juan Saenz Valiente 1010, Buenos Aires C1428BIJ, Argentina ; Instituto de Cálculo, FCEN, Universidad de Buenos Aires and CONICET, Argentina.
4
Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
5
Universidad Torcuato di Tella, Almirante Juan Saenz Valiente 1010, Buenos Aires C1428BIJ, Argentina.

Abstract

Combining resting-state functional magnetic resonance imaging (fMRI) connectivity and behavioral analysis during sedation, we factored out general effects of the anesthetic drug propofol and a specific index of conscious report, participants' level of responsiveness. The factorial analysis shows that increasing concentration of propofol in blood specifically decreases the connectivity strength of fronto-parietal cortical loops. In contrast, loss of responsiveness is indexed by a functional disconnection between the thalamus and the frontal cortex, balanced by an increase in connectivity strength of the thalamus to the occipital and temporal regions of the cortex.

PMID:
26509121
PMCID:
PMC4588413
DOI:
10.1016/j.nicl.2015.08.013
[Indexed for MEDLINE]
Free PMC Article

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