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PLoS Negl Trop Dis. 2015 Oct 27;9(10):e0004201. doi: 10.1371/journal.pntd.0004201. eCollection 2015.

Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice.

Author information

1
Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
2
Department of Neurology, Institute of Neurological Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
3
Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, Scotland, United Kingdom.

Abstract

Invasion of the central nervous system (CNS) by African trypanosomes represents a critical step in the development of human African trypanosomiasis. In both clinical cases and experimental mouse infections it has been demonstrated that predisposition to CNS invasion is associated with a type 1 systemic inflammatory response. Using the Trypanosoma brucei brucei GVR35 experimental infection model, we demonstrate that systemic delivery of the counter-inflammatory cytokine IL-10 lowers plasma IFN-γ and TNF-α concentrations, CNS parasitosis and ameliorates neuro-inflammatory pathology and clinical symptoms of disease. The results provide evidence that CNS invasion may be susceptible to immunological attenuation.

PMID:
26505761
PMCID:
PMC4624684
DOI:
10.1371/journal.pntd.0004201
[Indexed for MEDLINE]
Free PMC Article

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