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Ann Neurol. 2016 Jan;79(1):110-9. doi: 10.1002/ana.24546. Epub 2015 Dec 15.

Tau positron emission tomographic imaging in aging and early Alzheimer disease.

Johnson KA1,2,3,4,5, Schultz A1,4,6, Betensky RA7,8, Becker JA1,3, Sepulcre J1,3,5,6, Rentz D2,4,5, Mormino E2,4, Chhatwal J2,4,5, Amariglio R2,4,5, Papp K2,4,5, Marshall G2,4,5, Albers M2,5, Mauro S1,3, Pepin L1,3, Alverio J1,3, Judge K1,3, Philiossaint M1,3, Shoup T1,3, Yokell D1,3,5, Dickerson B1,2,5,6, Gomez-Isla T2,5, Hyman B2,5, Vasdev N1,3,5, Sperling R2,4,5,6.

Author information

1
Division of Nuclear Medicine and Molecular Imaging, Boston, MA.
2
Department of Neurology, Boston, MA.
3
Department of Radiology, Massachusetts General Hospital, Boston, MA.
4
Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Boston, MA.
5
Harvard Medical School, Boston, MA.
6
Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA.
7
Department of Medicine (Biostatistics Center), Massachusetts General Hospital, Boston, MA.
8
Harvard School of Public Health, Boston, MA.

Abstract

OBJECTIVE:

Detection of focal brain tau deposition during life could greatly facilitate accurate diagnosis of Alzheimer disease (AD), staging and monitoring of disease progression, and development of disease-modifying therapies.

METHODS:

We acquired tau positron emission tomography (PET) using (18)F T807 (AV1451), and amyloid-β PET using (11)C Pittsburgh compound B (PiB) in older clinically normal individuals, and symptomatic patients with mild cognitive impairment or mild AD dementia.

RESULTS:

We found abnormally high cortical (18)F T807 binding in patients with mild cognitive impairment and AD dementia compared to clinically normal controls. Consistent with the neuropathology literature, the presence of elevated neocortical (18)F T807 binding particularly in the inferior temporal gyrus was associated with clinical impairment. The association of cognitive impairment was stronger with inferior temporal (18)F T807 than with mean cortical (11)C PIB. Regional (18)F T807 was correlated with mean cortical (11)C PiB among both impaired and control subjects.

INTERPRETATION:

These findings suggest that (18)F T807 PET could have value as a biomarker that reflects both the progression of AD tauopathy and the emergence of clinical impairment.

PMID:
26505746
PMCID:
PMC4738026
DOI:
10.1002/ana.24546
[Indexed for MEDLINE]
Free PMC Article

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