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Cell Cycle. 2015;14(23):3679-88. doi: 10.1080/15384101.2015.1093712.

A perspective on stem cell modeling of amyotrophic lateral sclerosis.

Author information

1
a The Howard Hughes Medical Institute; The Harvard Stem Cell Institute; The Stanley Center for Psychiatric Research ; The Department of Stem Cell and Regenerative Biology ; Harvard University ; Cambridge , MA USA.
2
b Department of Anatomy & Embryology ; Leiden University Medical Center ; The Netherlands.

Abstract

Amyotrophic lateral sclerosis is a complex neurodegenerative disease. Limitations in animal models have impeded progress in studying disease pathology and potential drug discovery. Here, we will review recent advances in the development of stem cell models for the study of ALS. Additionally, we will discuss the progress toward therapeutic development derived from these stem cell based assays.

KEYWORDS:

Amyotrophic Lateral Sclerosis; astrocyte; embryonic stem cells; glia; induced pluripotent stem cells; microglia; motor neuron

PMID:
26505672
PMCID:
PMC4825790
DOI:
10.1080/15384101.2015.1093712
[Indexed for MEDLINE]
Free PMC Article

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