Quantitative analysis of mouse corpus callosum from electron microscopy images

Kathryn L West; Nathaniel D Kelm; Robert P Carson; Mark D Does

doi:10.1016/j.dib.2015.08.022

Quantitative analysis of mouse corpus callosum from electron microscopy images

Data Brief. 2015 Sep 3:5:124-8. doi: 10.1016/j.dib.2015.08.022. eCollection 2015 Dec.

Authors

Kathryn L West¹, Nathaniel D Kelm¹, Robert P Carson², Mark D Does³

Affiliations

¹ Department of Biomedical Engineering, Vanderbilt University, United States ; Vanderbilt University Institute of Imaging Science, Vanderbilt University, United States.
² Department of Pediatric Neurology, United States.
³ Department of Biomedical Engineering, Vanderbilt University, United States ; Vanderbilt University Institute of Imaging Science, Vanderbilt University, United States ; Department of Radiology and Radiological Sciences, Vanderbilt University School of Medicine, United States ; Department of Electrical Engineering, Vanderbilt University, United States.

Abstract

This article provides morphometric analysis of 72 electron microscopy images from control (n=4) and hypomyelinated (n=2) mouse corpus callosum. Measures of axon diameter and g-ratio were tabulated across all brains from two regions of the corpus callosum and a non-linear relationship between axon diameter and g-ratio was observed. These data are related to the accompanying research article comparing multiple methods of measuring g-ratio entitled 'A revised model for estimating g-ratio from MRI' (West et al., NeuroImage, 2015).

Keywords: G ratio; Histology; Hypomyelinated; MRI; Tuberous sclerosis.

Abstract

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