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J Cell Biol. 2015 Oct 26;211(2):215-7. doi: 10.1083/jcb.201510009.

MT1-MMP: Endosomal delivery drives breast cancer metastasis.

Author information

1
Institute for Medical Microbiology, Virology, and Hygiene, University Medical Center Eppendorf, 20246 Hamburg, Germany s.linder@uke.de.

Abstract

The membrane-tethered membrane type 1-matrix metalloproteinase (MT1-MMP) mediates proteolysis-based invasive tumor growth. In this issue, Marchesin et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201506002) describe a tug-of-war mechanism regulating dynein and kinesin motors to drive endosome tubulation and MT1-MMP delivery to the surface of cancer cells, identifying a crucial regulatory axis for tumor metastasis.

PMID:
26504163
PMCID:
PMC4621844
DOI:
10.1083/jcb.201510009
[Indexed for MEDLINE]
Free PMC Article

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