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Database (Oxford). 2015 Oct 26;2015. pii: bav106. doi: 10.1093/database/bav106. Print 2015.

Differential ligand-signaling network of CCL19/CCL21-CCR7 system.

Author information

1
Computational Biology Group, Cancer Research Program-9, Rajiv Gandhi Centre for Biotechnology, Thycaud, Poojappura, Thiruvanathapuram 690 014, Kerala, India and.
2
Institute of Bioinformatics, Discoverer, International Technology Park, Bangalore 560 066, Karnataka, India.
3
Computational Biology Group, Cancer Research Program-9, Rajiv Gandhi Centre for Biotechnology, Thycaud, Poojappura, Thiruvanathapuram 690 014, Kerala, India and reshmi@rgcb.res.in.

Abstract

Chemokine (C-C motif) receptor 7 (CCR7), a class A subtype G-Protein Coupled Receptor (GPCR), is involved in the migration, activation and survival of multiple cell types including dendritic cells, T cells, eosinophils, B cells, endothelial cells and different cancer cells. Together, CCR7 signaling system has been implicated in diverse biological processes such as lymph node homeostasis, T cell activation, immune tolerance, inflammatory response and cancer metastasis. CCL19 and CCL21, the two well-characterized CCR7 ligands, have been established to be differential in their signaling through CCR7 in multiple cell types. Although the differential ligand signaling through single receptor have been suggested for many receptors including GPCRs, there exists no resource or platform to analyse them globally. Here, first of its kind, we present the cell-type-specific differential signaling network of CCL19/CCL21-CCR7 system for effective visualization and differential analysis of chemokine/GPCR signaling. Database URL: http:// www. netpath. org/ pathways? path_ id= NetPath_ 46.

PMID:
26504105
PMCID:
PMC4620938
DOI:
10.1093/database/bav106
[Indexed for MEDLINE]
Free PMC Article

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