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Anticancer Res. 2015 Nov;35(11):6219-22.

A Tool to Estimate Survival of Elderly Patients Presenting with Metastatic Epidural Spinal Cord Compression (MESCC) from Cancer of Unknown Primary.

Author information

1
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany Rades.Dirk@gmx.net.
2
Department of Radiation Oncology, Consorcio Hospital Provincial de Castellón, Castellón, Spain.
3
Department of Radiotherapy, Dr. Bernard Verbeeten Institute, Tilburg, the Netherlands.
4
Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.

Abstract

AIM:

Cancers of unknown primary (CUP) account for about 10% in elderly patients with MESCC. Immediate treatment is indicated. Personalizing treatment for MESCC requires for clear understanding of the patients' survival prognosis. In this case, a tool for estimating survival would be valuable.

PATIENTS AND METHODS:

In 104 elderly CUP patients, nine factors were investigated: age, gender, performance score, number of affected vertebrae, ability to walk at presentation for radiotherapy, additional bone metastases, visceral metastases, time developing motor weakness, radiotherapy program.

RESULTS:

In multivariate analysis, the ability to walk (p=0.011) and visceral metastases (p<0.001) were associated with survival. The following scores were assigned: unable to walk=0, able to walk=1, visceral metastases=0, no visceral metastases=1. Three groups were formed (0, 1 and 2 points) with 6-month survival rates of 7%, 18% and 73% (p<0.001).

CONCLUSION:

This specific tool assists the physician to estimate survival and select for the most suitable radiotherapy program in elderly CUP patients with MESCC.

KEYWORDS:

Cancer of unknown primary; MESCC; elderly; radiation therapy; survival tool

PMID:
26504054
[Indexed for MEDLINE]
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