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Cell Res. 2015 Nov;25(11):1185-6. doi: 10.1038/cr.2015.125. Epub 2015 Oct 27.

New tricks from an old dog: Another synaptotoxic fragment from APP.

Author information

1
Department of Medicine, National University of Singapore, Singapore.
2
Department of Neurosciences, University of California San Diego, La Jolla, USA.

Abstract

In a surprising twist, a hitherto unrecognized cleavage of the amyloid precursor protein (APP) by η-secretase, followed by α- or β-secretase cleavage releases a novel APP proteolytic fragment, Aη, which causes synaptic injury.

PMID:
26503171
PMCID:
PMC4650427
DOI:
10.1038/cr.2015.125
[Indexed for MEDLINE]
Free PMC Article

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