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Dev Med Child Neurol. 2016 Jul;58(7):728-34. doi: 10.1111/dmcn.12947. Epub 2015 Oct 26.

Maternal medical conditions during pregnancy and gross motor development up to age 24 months in the Upstate KIDS study.

Author information

1
Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
2
Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
3
Department of Environmental Health Sciences, University at Albany School of Public Health, Albany, NY, USA.
4
Department of Epidemiology and Biostatistics, University at Albany School of Public Health, Albany, NY, USA.
5
CapitalCare Pediatrics-Troy, Troy, NY, USA.

Abstract

AIM:

We examined whether children of mothers with a medical condition diagnosed before or during pregnancy took longer to achieve gross motor milestones up to age 24 months.

METHOD:

We obtained information on medical conditions using self-reports, birth certificates, and hospital records in 4909 mothers participating in Upstate KIDS, a population-based birth cohort. Mothers reported on their children's motor milestone achievement at 4, 8, 12, 18, and 24 months of age.

RESULTS:

After adjustment for covariates (including pre-pregnancy body mass index), children of mothers with gestational diabetes took longer to achieve sitting without support (hazard ratio [HR]=0.84, 95% confidence interval [CI] 0.75-0.93), walking with assistance (HR=0.88, 95% CI 0.77-0.98), and walking alone (HR=0.88, 95% CI 0.77-0.99) than children of females with no gestational diabetes. Similar findings emerged for maternal diabetes. Gestational hypertension was associated with a longer time to achieve walking with assistance. These associations did not change after adjustment for gestational age or birthweight. Severe hypertensive disorders of pregnancy were related to a longer time to achieve milestones, but not after adjustment for perinatal factors.

INTERPRETATION:

Children exposed to maternal diabetes, gestational or pre-gestational, may take longer to achieve motor milestones than non-exposed children, independent of maternal obesity.

PMID:
26502927
PMCID:
PMC4846588
DOI:
10.1111/dmcn.12947
[Indexed for MEDLINE]
Free PMC Article

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