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Brain Inj. 2015;29(13-14):1667-73. doi: 10.3109/02699052.2015.1075250. Epub 2015 Oct 26.

Acute S100B in serum is associated with cognitive symptoms and memory performance 4 months after paediatric mild traumatic brain injury.

Author information

1
a Department of Paediatric Neurology , Development & Rehabilitation, University Children's Hospital Bern , Bern , Switzerland .
2
b Department of Clinical Chemistry , University Hospital Bern , Bern , Switzerland , and.
3
c Department of Paediatric Surgery , University Children's Hospital Bern , Bern , Switzerland.

Abstract

OBJECTIVE:

This study explored whether acute serum marker S100B is related with post-concussive symptoms (PCS) and neuropsychological performance 4 months after paediatric mild traumatic brain injury (mTBI).

RESEARCH DESIGN AND METHODS:

This prospective short-term longitudinal study investigated children (aged 6-16 years) with mTBI (n = 36, 16 males) and children with orthopaedic injuries (OI, n = 27, 18 males) as a control group. S100B in serum was measured during the acute phase and was correlated with parent-rated PCS and neuropsychological performance 4 months after the injury.

MAIN OUTCOMES AND RESULTS:

The results revealed no between-group difference regarding acute S100B serum concentration. In children after mTBI, group-specific significant Spearman correlations were found between S100B and post-acute cognitive PCS (r = 0.54, p = 0.001) as well as S100B and verbal memory performance (r = -0.47, p = 0.006). In children after OI, there were insignificant positive relations between S100B and post-acute somatic PCS. In addition, insignificant positive correlations were found between neuropsychological outcome and S100B in children after OI.

CONCLUSIONS:

S100B was not specific for mild brain injuries and may also be elevated after OI. The group-specific association between S100B and ongoing cognitive PCS in children after mTBI should motivate to examine further the role of S100B as a diagnostic biomarker in paediatric mTBI.

KEYWORDS:

Biomarker S100B serum; neuropsychological outcome; paediatric mild traumatic brain injury; post-concussive symptoms

PMID:
26502808
DOI:
10.3109/02699052.2015.1075250
[Indexed for MEDLINE]
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