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ACS Chem Biol. 2016 Jan 15;11(1):25-30. doi: 10.1021/acschembio.5b00439. Epub 2015 Nov 5.

Wall teichoic acids prevent antibody binding to epitopes within the cell wall of Staphylococcus aureus.

Author information

1
Department of Chemistry, Yale University , 225 Prospect Street, New Haven, Connecticut 06511, United States.

Abstract

Staphylococcus aureus is a Gram-positive bacterial pathogen that produces a range of infections including cellulitis, pneumonia, and septicemia. The principle mechanism in antistaphylococcal host defense is opsonization with antibodies and complement proteins, followed by phagocytic clearance. Here we use a previously developed technique for installing chemical epitopes in the peptidoglycan cell wall to show that surface glycopolymers known as wall teichoic acids conceal cell wall epitopes, preventing their recognition and opsonization by antibodies. Thus, our results reveal a previously unrecognized immunoevasive role for wall teichoic acids in S. aureus: repulsion of peptidoglycan-targeted antibodies.

PMID:
26502318
PMCID:
PMC5592732
DOI:
10.1021/acschembio.5b00439
[Indexed for MEDLINE]
Free PMC Article

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