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Viruses. 2015 Oct 16;7(10):5375-87. doi: 10.3390/v7102880.

Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?

Author information

1
School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK. bs12jr@leeds.ac.uk.
2
School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK. bs11s3jd@leeds.ac.uk.
3
School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK. M.Muller@leeds.ac.uk.
4
School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK. a.macdonald@leeds.ac.uk.

Abstract

Studies have highlighted the essential nature of a group of small, highly hydrophobic, membrane embedded, channel-forming proteins in the life cycles of a growing number of RNA viruses. These viroporins mediate the flow of ions and a range of solutes across cellular membranes and are necessary for manipulating a myriad of host processes. As such they contribute to all stages of the virus life cycle. Recent discoveries have identified proteins encoded by the small DNA tumor viruses that display a number of viroporin like properties. This review article summarizes the recent developments in our understanding of these novel viroporins; describes their roles in the virus life cycles and in pathogenesis and speculates on their potential as targets for anti-viral therapeutic intervention.

KEYWORDS:

DNA virus; papillomavirus; polyomavirus; viroporin

PMID:
26501313
PMCID:
PMC4632388
DOI:
10.3390/v7102880
[Indexed for MEDLINE]
Free PMC Article

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