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Med Image Comput Comput Assist Interv. 2015;9350:246-54. doi: 10.1007/978-3-319-24571-3_30.

Multi-scale and Multimodal Fusion of Tract-tracing, Myelin Stain and DTI-derived Fibers in Macaque Brains.

Author information

1
Northwestern Polytechnical University, Xi'an, Shaanxi, China.
2
The University of Georgia, Athens, USA, Athens, Georgia, United States.
3
Emory University, Atlanta, GA, United States.
4
Nanjing University of Science and Technology, Nanjing, Jiang-su, China.
5
Emory University, Atlanta, Georgia, United States.

Abstract

Assessment of structural connectivity patterns of brains can be an important avenue for better understanding mechanisms of structural and functional brain architectures. Therefore, many efforts have been made to estimate and validate axonal pathways via a number of techniques, such as myelin stain, tract-tracing and diffusion MRI (dMRI). The three modalities have their own advantages and are complimentary to each other. From myelin stain data, we can infer rich in-plane information of axonal orientation at micro-scale. Tract-tracing data is considered as 'gold standard' to estimate trustworthy meso-scale pathways. dMRI currently is the only way to estimate global macro-scale pathways given further validation. We propose a framework to take advantage of these three modalities. Information of the three modalities is integrated to determine the optimal tractography parameters for dMRI fibers and identify cross-validated fiber bundles that are finally used to construct atlas. We demonstrate the effectiveness of the framework by a collection of experimental results.

KEYWORDS:

DTI; Tract-tracing; atlas; multi-scale and multimodal fusion; myelin stain

PMID:
26501133
PMCID:
PMC4610137
DOI:
10.1007/978-3-319-24571-3_30
[Indexed for MEDLINE]
Free PMC Article

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