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J Int Soc Sports Nutr. 2015 Oct 20;12:40. doi: 10.1186/s12970-015-0101-z. eCollection 2015.

Effects of zeolite supplementation on parameters of intestinal barrier integrity, inflammation, redoxbiology and performance in aerobically trained subjects.

Author information

1
Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria ; Institute of Nutrient Research and Sport Nutrition, Graz, Austria.
2
Institute of Nutrient Research and Sport Nutrition, Graz, Austria.
3
SportchirurgiePlus, Graz, Austria.
4
Biovis Diagnostic MVZ GmbH, Limburg, Germany.
5
Institute of Physiological Chemistry, Medical University of Graz, Graz, Austria ; Institute of Laboratory Sciences, Dr Greilberger GmbH, Laßnitzhöhe, Austria.
6
Department of Surgery, Division of Transplantation Surgery, Medical University of Graz, Graz, Austria.
7
FH JOANNEUM Ltd, Graz, Austria.
8
Medical and Chemical Laboratory diagnostics Lorenz & Petek Ltd, Graz, Austria.
9
Institute of Pathophysiology and Immunology, Medical University of Graz, Graz, Austria.
10
Panaceo International Active Mineral Production GmbH, Villach, Austria.
11
Institute of Sport Science, University of Vienna, Vienna, Austria.

Abstract

BACKGROUND:

Zeolites are crystalline compounds with microporous structures of Si-tetrahedrons. In the gut, these silicates could act as adsorbents, ion-exchangers, catalysts, detergents or anti-diarrheic agents. This study evaluated whether zeolite supplementation affects biomarkers of intestinal wall permeability and parameters of oxidation and inflammation in aerobically trained individuals, and whether it could improve their performance.

METHODS:

In a randomized, double-blinded, placebo controlled trial, 52 endurance trained men and women, similar in body fat, non-smokers, 20-50 years, received 1.85 g of zeolite per day for 12 weeks. Stool samples for determination of intestinal wall integrity biomarkers were collected. From blood, markers of redox biology, inflammation, and DNA damage were determined at the beginning and the end of the study. In addition, VO2max and maximum performance were evaluated at baseline and after 12 weeks of treatment. For statistical analyses a 2-factor ANOVA was used.

RESULTS:

At baseline both groups showed slightly increased stool zonulin concentrations above normal. After 12 weeks with zeolite zonulin was significantly (p < 0.05) decreased in the supplemented group. IL-10 increased tendentially (p < 0.1) in the zeolite group. There were no significant changes observed in the other measured parameters.

CONCLUSIONS:

Twelve weeks of zeolite supplementation exerted beneficial effects on intestinal wall integrity as indicated via decreased concentrations of the tight junction modulator zonulin. This was accompanied by mild anti-inflammatory effects in this cohort of aerobically trained subjects. Further research is needed to explore mechanistic explanations for the observations in this study.

KEYWORDS:

Leaky gut; Tight junctions; Trained subjects; Zeolite supplementation; Zonulin

PMID:
26500463
PMCID:
PMC4617723
DOI:
10.1186/s12970-015-0101-z
[Indexed for MEDLINE]
Free PMC Article

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