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J Vet Intern Med. 2015 Nov-Dec;29(6):1564-8. doi: 10.1111/jvim.13643. Epub 2015 Oct 25.

The Clinical and Serological Effect of a Gluten-Free Diet in Border Terriers with Epileptoid Cramping Syndrome.

Author information

1
Davies Veterinary Specialists, Hitchin, UK.
2
Department of Clinical Sciences and Services, Royal Veterinary College, Hatfield, Hertfordshire, UK.
3
Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK.
4
Department of Pharmacology, UCL School of Pharmacy, London, UK.
5
Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield, UK.
6
Powell Torrance Diagnostic Services, Higham Gobion, UK.

Abstract

BACKGROUND:

Canine epileptoid cramping syndrome (CECS) is a paroxysmal movement disorder of Border Terriers (BTs). These dogs might respond to a gluten-free diet.

OBJECTIVES:

The objective of this study was to examine the clinical and serological effect of a gluten-free diet in BTs with CECS.

ANIMALS:

Six client-owned BTs with clinically confirmed CECS.

METHODS:

Dogs were prospectively recruited that had at least a 6-month history of CECS based on the observed phenomenology (using video) and had exhibited at least 2 separate episodes on different days. Dogs were tested for anti-transglutaminase 2 (TG2 IgA) and anti-gliadin (AGA IgG) antibodies in the serum at presentation, and 3, 6, and 9 months after the introduction of a gluten-free diet. Duodenal biopsies were performed in 1 dog.

RESULTS:

Serum TG2 IgA titers were increased in 6/6 BTs (P = .006) and AGA IgG titers were increased in 5/6 BTs at presentation compared to those of controls (P = .018). After 9 months, there was clinical and serological improvement in all BTs with CECS strictly adhering to a gluten-free diet (5/5). One dog had persistently increased antibody titers. This dog scavenged horse manure. On the strict introduction of a gluten-free diet this dog also had an improved clinical and serological response. The diet-associated improvement was reversible in 2 dogs on completion of the study, both of which suffered a relapse of CECS on the re-introduction of gluten.

CONCLUSIONS:

Canine epileptoid cramping syndrome in BTs is a gluten-sensitive movement disorder triggered and perpetuated by gluten and thus responsive to a gluten-free diet.

KEYWORDS:

Dyskinesia; Gluten hypersensitivity; Movement disorder; Neurology; Paroxysmal nonkinesigenic dyskinesia

PMID:
26500168
PMCID:
PMC4895653
DOI:
10.1111/jvim.13643
[Indexed for MEDLINE]
Free PMC Article

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