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Clin Biochem. 2016 Jan;49(1-2):70-8. doi: 10.1016/j.clinbiochem.2015.10.004. Epub 2015 Oct 21.

Erectile dysfunction and diabetes: Association with the impairment of lipid metabolism and oxidative stress.

Author information

1
Urological and Andrological Unit, Department of Medicine, Surgery and Neuroscience, University Hospital, Siena, Italy.
2
Department of Medical Biotechnologies, University of Siena, Siena, Italy. Electronic address: corteale@gmail.com.
3
Diabetes Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
4
Department of Ecological and Biological Sciences, University of Tuscia, Viterbo, Italy.
5
Department of Medical Biotechnologies, University of Siena, Siena, Italy.

Abstract

OBJECTIVES:

To test the hypothesis that exists an association of non-diabetic and diabetic patients suffering from erectile dysfunction (ED) with lipid metabolism and oxidative stress.

DESIGN AND METHODS:

Clinical and laboratory characteristics in non-diabetic (n = 30, middle age range: 41–55.5 years; n = 25, old age range: 55.5–73), diabetic ED patients (n = 30, age range: 55.5–75 years) and diabetic patients (n = 25, age range: 56–73.25), were investigated. Proteomic analysis was performed to identify differentially expressed plasma proteins and to evaluate their oxidative posttranslational modifications.

RESULTS:

A decreased level of high-density lipoproteins in all ED patients (P < 0.001, C.I. 0.046–0.10), was detected by routine laboratory tests. Proteomic analysis showed a significant decreased expression (P < 0.05) of 5 apolipoproteins (i.e. apolipoprotein H, apolipoprotein A4, apolipoprotein J, apolipoprotein E and apolipoprotein A1) and zinc-alpha-2-glycoprotein, 50% of which are more oxidized proteins. Exclusively for diabetic ED patients, oxidative posttranslational modifications for prealbumin, serum albumin, serum transferrin and haptoglobin markedly increased.

CONCLUSIONS:

Showing evidence for decreased expression of apolipoproteins in ED and the remarkable enhancement of oxidative posttranslational modifications in diabetes-associated ED, considering type 2 diabetes mellitus and age as independent risk factors involved in the ED pathogenesis, lipid metabolism and oxidative stress appear to exert a complex interplay in the disease.

KEYWORDS:

Diabetes; Erectile dysfunction; Lipid metabolism; Oxidative posttranslational modifications; Plasma proteome

[Indexed for MEDLINE]

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