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Tumour Biol. 2016 Apr;37(4):4439-44. doi: 10.1007/s13277-015-4288-z. Epub 2015 Oct 25.

Function analysis of rs9589207 polymorphism in miR-92a in gastric cancer.

Author information

1
Department of Clinical Laboratory, Kunshan Hospital Affiliated to Nanjing University of Chinese Medicine, Kunshan, Jiangsu, China. liuchangming313@sina.com.
2
Department of Clinical Laboratory, Kunshan Hospital Affiliated to Nanjing University of Chinese Medicine, Kunshan, Jiangsu, China.
3
Department of Oncological Surgery, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, Jiangsu, China.
4
Department of Clinical Laboratory, Wujin Hospital Affiliated to Jiangsu University, Changzhou, China.
5
Department of General Surgery, Wujin Hospital Affiliated to Jiangsu University, Changzhou, China.
6
Department of Clinical Laboratory, The 359th Hospital of PLA, Zhengjiang, China.

Abstract

MiR-92a was identified as an essential oncogene by promoting the cell proliferation through FBXW7 in gastric cancer (GC). The function of the single nucleotide polymorphism (SNP) located in the mature region of miR-92a (rs9589207) has not been investigated. We found that rs9589207 in miR-92a was involved in the occurrence of GC by acting as a tumor protective factor and was highly associated with tumor size in GC patients instead of tumor number or metastasis in 554 GC patients and 531 cancer-free controls. Besides, the AA genotype in miR-92a could attenuate the promoting function of miR-92a in cell proliferation with an incapacitation in downregulating the expression of FBXW7. In conclusion, rs9589207 in miR-92a was highly associated with a decreased risk of GC in Chinese Han population and might serve as a novel biomarker for the disease.

KEYWORDS:

FBXW7; Genotype; MiR-92a; SNP; Tumor growth

PMID:
26499948
DOI:
10.1007/s13277-015-4288-z
[Indexed for MEDLINE]

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