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Nat Prod Res. 2016;30(9):1025-9. doi: 10.1080/14786419.2015.1101693. Epub 2015 Oct 23.

A new polyketide, penicillolide from the marine-derived fungus Penicillium sacculum.

Author information

1
a Department of Natural Products Chemistry, School of Pharmacy , China Medical University , Shenyang , China.
2
b Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang , China.
3
c Department of the Central Laboratory, School of Pharmacy , China Medical University , Shenyang , China.
4
d Qingdao Key Lab of Analytical Technology Development and Standardization of Chinese Medicines , The First Institute of Oceanography SOA , Qingdao , China.
5
e Department of Biology , Qingdao University of Science & Technology , Qingdao , China.

Abstract

A new polyketide, penicillolide (1) was isolated from the fermentation broth of the marine-derived fungus Penicillium sacculum GT-308. Compound 1 is a polyketide with a unique carbon skeleton. The structure of this compound was established via extensive spectroscopic analyses including 1D-, 2D-NMR, and HRESI-MS.

KEYWORDS:

Marine-derived fungus; Penicillium sacculum; penicillolide; polyketide

PMID:
26499896
DOI:
10.1080/14786419.2015.1101693
[Indexed for MEDLINE]

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